Multisystem inflammatory syndrome in children (MIS-C) occurs 3-6 weeks after COVID-19. Clinical symptoms of MIS-C include fever, rash, conjunctivitis, gastrointestinal or other organ symptoms, including cardiac dysfunction. The incidence of MIS-C is 2 / 100 000 children with SARS-CoV-2.It is crucial to know why MIS-C is not observed in all children after COVID-19. To date, several candidate genes associated with the development of MIS-C have been proposed as predisposing factors. The small number of proposed genes is probably also related to the relatively small size of the cohorts of children with MIS-C. A large number of studies related to genetic predisposition to this condition are not yet available. This review describes the studies that have been published up to date. The full text of the article can be read here.