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Ocular sequelae of epidermal necrolysis

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Stevens-Johnson Syndrome (SJS) and toxic epidermal necrolysis (TEN) are serious and rare diseases, most often drug-induced, and their incidence has been estimated at 6 cases/million/year in France. SJS and TEN belong to the same spectrum of disease known as epidermal necrolysis (EN). They are characterized by more or less extensive epidermal detachment, associated with mucous membrane involvement, and may be complicated during the acute phase by fatal multiorgan failure. SJS and TEN can lead to severe ophthalmologic sequelae. There are no recommendations for ocular management during the chronic phase. A national audit of current practice in the 11 sites of the French reference center for toxic bullous dermatoses and a review of the literature is conducted to establish therapeutic consensus guidelines. Ophthalmologists and dermatologists from the French reference center for epidermal necrolysis are asked to complete a questionnaire on management practices in the chronic phase of SJS/TEN. Based on the results from the survey and literature review, an evaluation form to facilitate ophthalmic data collection in the chronic phase of EN is proposed and also an algorithm for the ophthalmologic management of ocular sequelae is recommended. Read the full article here.

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