In the daily routine of the dental practitioners there are patients with blood disorders and the most common coagulopathy is haemophilia. The aim of this article is to analyze data from publications exploring the oral status and the causes that could lead to oral haemorrhage in patients with haemophilia. A systematic search was conducted in PubMed database for all available publications until December 2018 that examined the oral status and the causes that could lead to oral haemorrhage in children and adults with haemophilia. It is approved that there is no significant difference between adult patients with haemophilia and their control groups and the oral status of the children with hemophilia is better. Compared to healthy controls, patients experience greater bleeding of the gingiva at rest and dental invasive manipulations. Therefore for prevention of the complications should be provided clinical guidelines for the dental procedures. The full article you can read on the latest issue of our journal “Rare diseases and orphan drugs” here.