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The new edition of “Rare Diseases & Orphan Drugs” is already published on our website. The cover story presents the health technology assessment (HTA). Dr. Edmund Jessop and Ms. Jacqueline Bowman would discuss the features of this concept, as well as its potential benefits for patients and physicians. The issue summarises the most important achievements of 2012 – both for Bulgaria and Europe. “Rare Diseases Library” reviews a rare disorder, named Friedreich Ataxia. You will also find many other interesting articles in our newsletter. Hapy holidays!