Constant blood flow reduction in premotor frontal lobe regions in ALS with dementia

PubMed, the Internet portal of biomedical and life sciences literature, indexed an interesting article, entitled Constant blood flow reduction in premotor frontal lobe regions in ALS with dementia – a SPECT study with 3D-SSP (Acta Neurol Scand. 2007 Nov;116(5):340-4.). Authors are Ishikawa T , Morita M Nakano I et al, from the Division of Neurology, Department of Internal Medicine, Jichi Medical University, Tochigi, Japan. We investigated the regional cerebral blood flow in amyotrophic lateral sclerosis with dementia (ALS-D) patients, using single photon emission computed tomography (SPECT). The (123)I-IMP SPECT data for 5 ALS-D and 16 ALS patients were analyzed using three-dimensional stereotactic surface projection (3D-SSP). RESULTS – 3D-SSP demonstrated marked prefrontal hypoperfusion in all the five ALS-D cases and significant bilateral prefrontal hypoperfusion in group comparisons. This study revealed prefrontal hypoperfusion in ALS-D cases to be an obvious abnormality with scientific objectivity. To access the full abstract of the article, click here