Beta-thalassemia is one of the most common autosomal-recessive disorders. The advances in the chelator treatment and the non-invasive methods for the assessment and follow up of the iron overload have led to an improved quality and longer duration of the life of patients with thalassemia. The liver is the primer target organ affected both directly and indirectly. In this article are reviewed the most common liver complications such as liver fibrosis and cirrhosis, non-invasive methods for evaluation of the iron deposition, chronic viral hepatitis, hepatocellular carcinoma and cholelithiasis. Read the full article here.