PubMed, the Internet portal of biomedical and life sciences literature, indexed an interesting article, entitled Asymptomatic thyroid tuberculosis in a multinodular goitre patient: a case report. (Acta Chir Belg. 2007 Jul-Aug;107(4):457-9.). Authors are Girgin S Gedik E Büyükbayram H. from the Department of General Surgery,School of Medicine, University of Dicle, Diyarbakir, Turkey. Thyroid tuberculosis is a very rare disease of the thyroid gland. In recent years, the incidence of extra-pulmonary tuberculosis has been showing a progressive increase. We present the case of a 41-year old female patient, operated for an asymptomatic multinodular goiter, and who had a histopathological diagnosis of thyroid tuberculosis. Thyroid tuberculosis should be kept in mind in the differential diagnosis of thyroid nodules, even in patients with no history and no symptom of tuberculosis disease. To access the full abstract of the article, click here.
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On 23/10/2007, a new orphan medicinal product was registered into the community register of orphan medicinal products under the EU orphan designation number 493. The active ingredient is Isofagomine tartrate for treatment of Gaucher Disease.
PubMed, the Internet portal of biomedical and life sciences literature, indexed an interesting article, entitled hereditary angioedema: a case study (J Neurosci Nurs. 2007 Oct;39(5):311-5). Author is Vacca VM Jr. from the Neuroscience Intensive Care Unit, Brigham and Women’s Hospital, Boston, MA, USA. Hereditary angioedema (HAE) is an autosomal dominant trait. It manifests as attacks of swelling involving the extremities, trunk, abdominal viscera, face, neck, or airway. The attacks may occur spontaneously, without any identifiable trigger, or may be the result of a specific trigger, such as a minor tissue trauma.Treatment for an acute attack is largely supportive, including administration of epinephrine and antihistamines to maintain a patent, reliable airway. Shortterm prophylaxis includes fresh frozen plasma and corticosteroids. Long-term prophylaxis includes use of androgens and antifibrinolytics, as well as the avoidance of known triggers. Prior to the advent of such therapies, mortality from an acute attack of HAE was reported as high as 30%. To access the full abstract of the article, click here.
On 22/10/2007, a new orphan medicinal product was registered into the community register of orphan medicinal products under the EU orphan designation number 496. The active ingredient is Mercaptopurine (oral liquid) for treatment of acute lymphoblastic leukaemia.
PubMed, the Internet portal of biomedical and life sciences literature, indexed an interesting article, entitled Squamous cell carcinoma of the nasal columella: a retrospective study of 66 cases from the GETTEC (Eur Arch Otorhinolaryngol. 2007 Oct 26). Authors are Choussy O Babin E Temam S et al., from the ENT Department, Rouen University Hospital, 1, rue de Germont, 76031, Rouen, France. Squamous cell carcinoma of the nasal columella (SCCNC) is a rare disease.Medical records of 66 patients presenting with columella squamous cell carcinoma in nine French hospitals, from 1980 to 2003, were evaluated to determine the clinical characteristics and current treatment of the disease. Patients underwent one of the three treatments: surgery alone for the T1 lesions, radiotherapy for tumors of T2-T3 and combined (surgery and radiotherapy) for T4 lesions. The 5-year Kaplan-Meier survival test was 39% and no difference was found between the therapeutic groups. SCCNC is difficult to manage and has a poor prognosis. No therapeutic solution has yet been confirmed in the treatment of this pathology. To access the full abstract of the article, click here.
PubMed, the Internet portal of biomedical and life sciences literature, indexed an interesting article, entitled Focal Epithelial Hyperplasia (Actas Dermosifiliogr. 2007 Nov;98(9):621-623.). Authors are Vera-Iglesias E García-Arpa M Sánchez-Caminero P et al., from the Servicio de Dermatología. Hospital General de Ciudad Real, Spain. Focal epithelial hyperplasia is a rare disease of the oral mucosa caused by the human papilloma virus (HPV). It appears as a benign epithelial growth, usually in the mucosa of the lower lip. It is mainly associated with HPV serotypes 13 and 32 and there is a clear racial predilection for the disease in Native Americans and Eskimos. We describe the case of a 17-year-old girl from Ecuador with multiple papular lesions in both lips that were clinically and histologically consistent with focal epithelial hyperplasia. Analysis by polymerase chain reaction detected HPV serotype 13. To access the full abstract of the article, click here.
PubMed, the Internet portal of biomedical and life sciences literature, indexed an interesting article, entitled Non-compaction on autopsy in Duchenne muscular dystrophy (Cardiology. 2007;108(3):161-3. Epub 2006 Oct 23). Authors are Finsterer J Stöllberger C Feichtinger H from the Krankenanstalt Rudolfstiftung, Vienna, Austria. Left ventricular hypertrabeculation (LVHT) is frequently associated with neuromuscular disorders. Recently, LVHT has been detected in a 28-year patient with Duchenne muscular dystrophy. Here, the patho-anatomic findings of this patient are presented, which showed LVHT located within in the apex and the anterior and lateral wall, being the most demanded segments during systole. The septum and the left ventricular outflow tract were not involved. The patho-anatomic specimen also showed aberrant bands and false tendons, a frequent finding in hearts with LVHT. The patho-anatomic findings were in line with those of LVHT patients with or without neuromuscular disorders To access the full abstract of the article, click here.
On 24/10/2007, a new orphan medicinal product was registered into the community register of orphan medicinal products under the EU orphan designation number 495. The active ingredient is Methotrexate (oral liquid) for treatment of acute lymphoblastic leukaemia.
PubMed, the Internet portal of biomedical and life sciences literature, indexed an interesting article, entitled Recognizing involuntary emotional expression disorder. (J Neurosci Nurs. 2007 Aug;39(4):202-7). Authors are Robinson-Smith G and Grill JD from the Villanova University’s College of Nursing, Villanova, PA, USA. Involuntary crying or laughing are symptoms of a condition known as involuntary emotional expression disorder (IEED). This disorder is common among patients with stroke and other neurological disorders, such as multiple sclerosis, amyotrophic lateral sclerosis, and traumatic brain injury.IEED can become disabling for patients who are not accurately diagnosed and treated. When the condition is found to be present, effective management must include education, pharmacological treatment, and teaching of self-care strategies. To access the full abstract of the article, click here.
On 14/09/2007, a new orphan medicinal product was registered into the community register of orphan medicinal products under the EU orphan designation number 473. The active ingredient is Aviptadil for treatment of sarcoidosis.